eCollection 2020 Jan-Dec. Nery de Albuquerque Rego G, da Hora Alves A, Penteado Nucci M, Bustamante Mamani J, Anselmo de Oliveira F, Gamarra LF. AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications. Pilli VS, Datta A, Dorsey A, Liu B, Majumder R. Oncol Rep. 2020 Oct;44(4):1322-1332. doi: 10.3892/or.2020.7689. Each has been implicated in MERTK physiologic and oncogenic functions. Huey MG, Minson KA, Earp HS, DeRyckere D, Graham DK. Lee-Sherick AB, Jacobsen KM, Henry CJ, Huey MG, Parker RE, Page LS, Hill AA, Wang X, Frye SV, Earp HS, Jordan CT, DeRyckere D, Graham DK.
JCI Insight. [provided by RefSeq, Jul 2008], Intercellular Signaling Peptides and Proteins. R01 CA137078/CA/NCI NIH HHS/United States, NCI CPTC Antibody Characterization Program. In this review we discuss MERTK inhibition as an emerging strategy for cancer therapy, focusing on MERTK expression and function in neoplasia and its role in mediating resistance to cytotoxic and targeted therapies as well as in suppressing anti-tumor immunity.
MERTKis a promising therapeutic target in several tumor entities, however, its role in HNSCC has not been described yet. Cite this page: Cotterill SJ.
However, MERTK is overexpressed or ectopically expressed in a wide variety of cancers, including leukemia, non-small cell lung cancer, glioblastoma, melanoma, prostate cancer, bre … National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. HHS 2020 Jun 3;2(1):vdaa065. 2020 May 5;11(1):2206. doi: 10.1038/s41467-020-16067-1. MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
Molecular Pathways: AXL, a Membrane Receptor Mediator of Resistance to Therapy. The receptor tyrosine kinase MERTK is aberrantly expressed in numerous human malignancies, and is a novel target in cancer therapeutics. Akhavanfard S, Padmanabhan R, Yehia L, Cheng F, Eng C. Nat Commun.
2014 Sep 12;289(37):25737-49. doi: 10.1074/jbc.M114.570838. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. eCollection 2016. Knubel KH, Pernu BM, Sufit A, Nelson S, Pierce AM, Keating AK. 2019 Nov 4;18(1):153. doi: 10.1186/s12943-019-1090-3. MERTK, Cancer Genetics Web: http://www.cancer-genetics.org/MERTK.htm Accessed: This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.Note: content of abstracts copyright of respective publishers - seek permission where appropriate. Clipboard, Search History, and several other advanced features are temporarily unavailable. These macrophages serve as a promising target for treatment of cancer due to their roles in promoting cancer progression and simultaneous immunosuppression. 2020 Jun 24;21(12):4490. doi: 10.3390/ijms21124490. 2018 Nov 2;3(21):e97941.
NIH doi: 10.1093/noajnl/vdaa065. Clin Cancer Res. Epub 2016 Jan 13. Nguyen KQ, Tsou WI, Calarese DA, Kimani SG, Singh S, Hsieh S, Liu Y, Lu B, Wu Y, Garforth SJ, Almo SC, Kotenko SV, Birge RB. MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme. COVID-19 is an emerging, rapidly evolving situation.
Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. doi: 10.1172/jci.insight.97941. Get the latest research from NIH: https://www.nih.gov/coronavirus. NIH However, MERTK is overexpressed or ectopically expressed in a wide variety of cancers, including leukemia, non–small cell lung cancer, glioblastoma, melanoma, prostate cancer, breast cancer, colon cancer, gastric cancer, pituitary adenomas, and rhabdomyosarcomas, potentially resulting in the activation of several canonical oncogenic signaling pathways. 2020 Apr;52(4):569-581. doi: 10.1038/s12276-020-0423-z. Copyright © 2020 Elsevier Inc. All rights reserved. Zhang L, DeBerge M, Wang J, Dangi A, Zhang X, Schroth S, Zhang Z, Thorp EB, Luo X.
Finally, through MERTK, apoptotic cells induced PD-L1 expression, an immune checkpoint blockade, suggesting that cancer cells may adopt MERTK-driven efferocytosis as an immune suppression mechanism for their advantage. Cancers (Basel).
Frejno M, Zenezini Chiozzi R, Wilhelm M, et al. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). MERTK (myeloid-epithelial-reproductive tyrosine kinase) is a receptor tyrosine kinase (RTK) that is frequently abnormally expressed in a broad range of human cancers (Graham, DeRyckere, Davies, & Earp, 2014; Linger, Keating, Earp, & Graham, 2008).
Declaration of Competing Interest Diana Fridlyand – The author declares that there are no conflicts of interest Justus Huelse – The author declares that there are no conflicts of interest Shelton Earp – The author holds equity in Meryx incorporated and is on the Meryx board of directors Deborah DeRyckere – The author holds equity in Meryx incorporated Douglas K. Graham – The author holds equity in Meryx incorporated and is on the Meryx board of directors, NLM MERTK; anti-tumor immunity; clinical trials; neoplasia; preclinical agents. These data collectively identify MERTK as a significant link between cancer progression and efferocytosis, and a potentially unrealized tumor-promoting event when MERTK … COVID-19 is an emerging, rapidly evolving situation. | The force awakens: metastatic dormant cancer cells. Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic. | Sufit A, Lee-Sherick AB, DeRyckere D, Rupji M, Dwivedi B, Varella-Garcia M, Pierce AM, Kowalski J, Wang X, Frye SV, Earp HS, Keating AK, Graham DK. Epub 2020 Apr 16. Conversely, MERTK inhibition by genetic or pharmacologic means can reverse these pro-oncogenic phenotypes.
USA.gov. MERTK International Cancer Genome Consortium.Summary of gene and mutations by cancer type from ICGC, MERTK Cancer Genome Anatomy Project, NCIGene Summary, MERTK COSMIC, Sanger InstituteSomatic mutation information and related details. MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used). Am J Transplant. doi: 10.1371/journal.pone.0165107. | Exp Mol Med.
2016 Oct 26;11(10):e0165107. MERTK; MER proto-oncogene, tyrosine kinase: Aliases: MER, RP38, c-Eyk, c-mer, Tyro12 : Location: 2q13 : Summary: This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is a receptor tyrosine kinase of the TAM (Tyro3, Axl, MERTK) family, with a defined spectrum of normal expression.
2015 Sep;14(9):2014-22. doi: 10.1158/1535-7163.MCT-15-0116.
| P50 CA217691/CA/NCI NIH HHS/United States, T32 HL139443/HL/NHLBI NIH HHS/United States. Here we report the effect of treatment with a MERTK-selective small molecule inhibitor, … Epub 2020 Jul 15. The MERTK receptor tyrosine kinase is aberrantly expressed in melanoma and can contribute to oncogenic phenotypes. Epub 2015 Jul 10. Schmidt J, Guillaume P, Dojcinovic D, et al. Immune-mediated tumor rejection and inhibition of PD-1 signaling may be particularly important therapeutic mechanisms in melanoma, which is an immunotherapy-responsive disease. Smart SK, Vasileiadi E, Wang X, DeRyckere D, Graham DK.
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